Indication

Indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.(T2DM).

Dosage and Administration

Always once-daily dosing. Administer 1 tablet once daily with or without food.

Renal Dose Adjustments

Mild renal impairment (eGFR 45 mL/min/1.73 m2 or greater): No adjustment recommended.
Moderate renal impairment (eGFR 30 mL/min/1.73 m2 to less than 45 mL/min/1.73 m2): 50 mg orally once a day.
Severe renal impairment (eGFR less than 30 mL/min/1.73 m2): 25 mg orally once a day.

Liver Dose Adjustments

Mild or moderate hepatic impairment: No adjustment recommended.
Severe hepatic impairment: Use caution; no data available.

Dialysis

Hemodialysis: 25 mg orally once a day.
Peritoneal dialysis: 25 mg orally once a day.
May be administered without regard to timing of dialysis.

Administration advice

May take with or without food
Missed doses should be taken as soon as the patient remembers. More than one dose should not be taken on the same day.

Contraindications

Sitagliptin Phosphate should not be used in patients with type 1 diabetes or with diabetic ketoacidosis (increased ketones in the blood or urine). If you have had pancreatitis (inflammation of the pancreas), it is not known if you have a higher chance of getting it while taking Sitagliptin.